ABSTRACT:
OBJECTIVE To evaluate the incidence and epidemiological profile of meniscal ramp
lesions in patients undergoing anterior cruciate ligament (ACL)
reconstruction surgery, and to determine the related risk factors.
METHODS In total, 824 patients undergoing ACL reconstruction surgery were
retrospectively analyzed. Patients who presented medial meniscal instability
were submitted to evaluation of the posteromedial compartment of the knee.
In case of injury, surgical repair was performed. Potential risk factors
associated with the lesions were analyzed.
RESULTS The overall incidence of ramp lesions in the population studied was of 10.6%
(87 lesions in 824 patients). The multivariate analysis through the
Chi-squared test showed that the presence of meniscal ramp lesions was
significantly associated with the following risk factors: right laterality
and chronic lesions. Gender, age and sports activity were not statistically
significant. Soccer was the most frequent cause of ramp injuries related to
sport, with 78.2% of the cases. However, it was not shown to be a risk
factor. The annual incidence from 2014 to 2019 ranged from 4.0% to
20.6%.
CONCLUSION The incidence of meniscal ramp lesions was of 10.6% in ACL reconstruction
surgeries, being more frequent among patients with chronic lesions. The
increasing annual incidence ranged from 4.0% in 2014 to 20.6% in 2019.
Keywords: arthroscopy; epidemiology; knee; suture.
RESUMO:
OBJETIVO Avaliar a incidência e o perfil epidemiológico das lesões da rampa meniscal
nos pacientes submetidos a cirurgia de reconstrução do ligamento cruzado
anterior (LCA), e determinar os fatores de risco relacionados.
MÉTODOS Foram analisados retrospectivamente 824 pacientes submetidos a cirurgia de
reconstrução do LCA. Os pacientes que apresentaram instabilidade meniscal
medial foram submetidos a avaliação do compartimento posteromedial do
joelho. Em caso de lesão, o reparo cirúrgico foi realizado. Potenciais
fatores de risco associados às lesões foram analisados. Resultados A
incidência geral de lesões da rampa na população estudada foi de 10,6% (87
lesões em 824 pacientes). A análise multivariada pelo teste do Qui-quadrado
demonstrou que a presença de lesões da rampa meniscal foi significativamente
associada aos seguintes fatores de risco: lateralidade direita e lesões
crônicas. Sexo, idade e atividade esportiva não foram estatisticamente
significantes. O futebol foi a causa mais frequente de lesões da rampa
relacionadas ao esporte, com 78,2% dos casos. No entanto, não se mostrou ser
um fator de risco. De 2014 a 2019, a incidência anual variou de 4,0% a
20,6%.
CONCLUSÃO A incidência das lesões da rampa meniscal foi de 10,6% nas cirurgias de
reconstrução do LCA, sendo mais frequente em pacientes com lesões crônicas.
A incidência anual foi crescente, e variou de 4,0%, em 2014, a 20,6%, em
2019.
Palavras-chave: artroscopia; epidemiologia; joelho; sutura.
FIGURES
| Citation: Abreu FG, Canuto SMG, Canuto MMG, Chagas EF, Zutin TLM, Pádua VBC. Incidence of Meniscal Ramp Lesion in Anterior Cruciate Ligament Reconstructions* . 57(03):422. doi:10.1055/s-0041-1735942 |
| Financial Support The authors have no sources of funding to declare. |
|
*Work developed at Clínica Sportsmed, São José do Rio Preto, SP; at the Department of Orthopedics and Traumatology, Universidadede Marília, Marília, SP; and Ortoclínica Hospital de Ortopedia, Maceió, AL, Brazil. |
|
Conflict of Interests The authors have no conflict of interests to declare. |
| Received: December 04 2020; Accepted: June 02 2021 |
INTRODUCTION
Meniscal ramp lesions are commonly associated with anterior cruciate ligament (ACL) ruptures. A ramp lesion consists of meniscosynovial or meniscocapsular ruptures, which can be difficult to diagnose arthroscopically from the anterior compartment, and which significantly increase the anteroposterior and rotational instability of the knee when compared to isolated ACL lesions.1-4 Initially studied by Hamberg (apud Strobel5), the term “ramp lesion” was firstly attributed to these lesions to differentiate them from other classical lesions of the posterior part of the medial meniscus.
Although there is a long history of recognition of meniscal ramp lesions, the topic has been little studied in recent decades. This lack of previous importance attributed to the topic is a consequence of factors such as the low sensitivity of magnetic resonance imaging (MRI), with a high number of false-negatives, insufficient knowledge about its biomechanical consequences, and an intuitive sense that these lesions can heal spontaneously.3,6 In addition, the lesion is located in a “blind spot” of the posteromedial compartment of the knee, which makes it difficult to visualize through conventional arthroscopic portals, requiring the surgeon to have a more accurate technical ability to access and repair.7 In 2014, Sonnery-Cottet et al.8 introduced the concept of “occult lesions”, for meniscal ramp lesions that are not visible by conventional arthroscopic approaches, proposing a systematic exploration of the posterior segment of the medial meniscus by a posteromedial arthroscopy route.
The precise diagnosis of ramp lesions is also a challenge for radiologists. In 2017, DePhillippo et al.9 published an article showing a poor correlation between imaging and arthroscopy, with more than half of the cases being underdiagnosed preoperatively. Edema in the bone marrow in the posteromedial region of the medial tibial plateau appears to be a suggestive radiological sign, being present in 72% of the cases of meniscal ramp lesion.9
Although there are still no data on the epidemiology of ramp lesions in the Brazilian population, the international literature shows an incidence between 9% and 24% in ACL reconstructions (ACLRs).1,6,7,10 The aim of the present study is to evaluate the incidence and epidemiological profile of meniscal ramp lesions in patients undergoing ACLR, and to identify possible risk factors associated with these lesions.
MATERIALS AND METHODS
A retrospective analysis of the data of 824 ACLRs was performed through a consultation of hospital records. The inclusion criterion was patients submitted to primary or revision ACLR between July 2014 and April 2020. Patients undergoing concomitant surgeries, such as multiligament reconstructions or osteotomies, were excluded. Preoperatively, all patients had a complete rupture of the ACL, diagnosed based on clinical examination and MRI scans. The study was approved by plataforma Brasil under CAAE number 27216819.2.0000.5496
Surgical Technique
The surgical procedures were performed by two surgeons who are specialists in knee surgery and have great experience in ACLRs. The patients were positioned in a standard way for arthroscopy (►Figure 1). Meniscal and/or clinker lesions were addressed before ligament reconstruction.
Initially, arthroscopic exploration of the knee compartments was performed. In cases on which there was any sign of meniscal instability, such as increased anterior displacement under traction, or when a fissure was observed in its lower leaflet, an investigation was carried out in the posteromedial compartment, as proposed by Sonnery-Cottet et al. 8
For the evaluation of the posteromedial compartment of the knee, the arthroscope is maintained in the anterolateral portal and inserted through a space in the intercondyle defined by the medial femoral condyle, posterior cruciate ligament (PCL), and tibia (►Figure 2).
In cases in which a meniscus fissure (ramp injury) was observed, repair was performed. When there was also suspicion of the presence of a hidden ramp injury (type D),11 meniscal integrity was tested with a needle, and then with a probe, inserted through a posteromedial portal. The preparation of the posteromedial portal was made through transillumination, which assistis in the visualization of veins to nerves that must be preserved (►Figure 3). The shaver blade was then inserted through the posteromedial portal, and both surfaces of the lesion were scraped (►Figure 4).
For the sutures, a 25o suture hook (SutureLasso, Arthrex, Naples, FL, United States) loaded with an absorbable monofilament thread no. 1 (PDS, Ethicon, Inc., Somerville, NJ, United States) was used. The preparation of the stitches with sliding knots was carried out with the help of a knot pusher (►Figure 5). The satisfactory and stable repair was confirmed by evaluation using the probe inserted through the anterolateral and posteromedial portals. Finally, the ACLR procedure was performed with the preparation of independent anatomical tunnels (outsidein), according to the Chambat technique.12,13 Patients submitted to ramp lesion repair followed the same rehabilitation protocol.
Statistical Analysis
The quantitative variables were described by means and minimum and maximum values. The qualitative variables were described by the distribution of absolute and relative frequencies (%). The analysis of the relationship among the qualitative variables was performed by the Chi-squared association test. The total and yearly proportions of cases were analyzed by the incidence rates and their respective 95% confidence intervals (95%CIs), and they were calculated by dividing the number of confirmed cases and the aggregate of the population exposed in the period and expressed by 100. The level of statistical significance adopted was of 5%, and the data were analyzed using the Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY, United States) software, version 24.0.
RESULTS
The total number of patients submitted to ACLR included in the present study was 824. Meniscal ramp lesion was observed and repaired in 87 (10.6%) patients. The characteristics of the patients diagnosed with ramp lesion are shown in ►Table 1.
| Characteristics | With injury- n (%) | No injury- n (%) | p-value |
|---|---|---|---|
| Gender | |||
| Male | 76 (87.3%) | 631 (85.6%) | 0.718 |
| Female | 11 (12.7%) | 109 (14.4%) | |
| Laterality | |||
| Right | 61 (70.1%) | 403 (54.7%) | 0.008* |
| Left | 26 (29.9%) | 337 (45.3%) | |
| Ligament reconstruction | |||
| Primary | 80 (91.9%) | 694 (94.2%) | 0.562 |
| Revision | 7 (8.1%) | 43 (5.4%) | |
| Age (years) | |||
| < 20 | 6 (6.9%) | 102 (13.8%) | 0.053 |
| 20-30 | 44 (50.6%) | 267 (36.2%) | |
| 31-40 | 26 (29.9%) | 255 (34.6%) | |
| > 40 | 11 (12.6%) | 119 (15.4%) | |
| Average | 29.9 (17-49) | 31.4 (13-71) | |
| Injury time (months) | |||
| < 3 | 28 (32.2%) | 362 (49.1%) | 0.008* |
| 4-6 | 14 (16.1%) | 102 (13.8%) | |
| 7-12 | 15 (17.2%) | 79 (10.7%) | |
| 13-24 | 14 (16.1%) | 58 (7.9%) | |
| > 24 | 16 (18.4%) | 136 (18.5%) | |
| Average | 16.4 (1-120) | 19.7 (1-360) |
Of the total number of patients with meniscal ramp injury, 76 (87.3%) were male, and 11 (12.7%), female. The mean age in this group was of 29.9 years (range: 17 to 49 years). From the 87 ACL reconstructions with associated ramp injury, 80 (91.9%) were primary surgeries, and 7 (8.1%) were reviews, but with no statistical significance between the groups (p = 0.562). Regarding laterality, the right knee was affected in 61 cases (70.1%), and the left knee in 26 (29.9%), which was statistically significant (p = 0.008). The time between the lesion and ACLR was also statistically significant (p = 0.008). In cases in which there was ramp injury, this time was of up to 3 months (28 cases; 32.2%); between 4 and 6 months (14 cases; 16.1%); between 7 and 12 months (15 cases; 17.2%); between 13 and 24 months 14 cases; 16.1%); and longer than 24 months (16 cases; 18.4%), with an average of 16.4 months (range: 1 to 120 months). In cases in which ramp lesions were not diagnosed, 362 (49.1%) had up to 3 months of injury; 102 (13.8%), from 4 to 6 months; 79(10.7%), from 7 to 12 months; 58 (7.9%), from 13 to 24; and 136 (18.5%), for more than 24 months, with an average of 19.7 months (range: 1 to 360 months).
Trauma related to sports or physical activities accounted for 76 (87.4%) of the total number of cases. Among these, soccer was the most frequent cause, with 68 cases (78.2%) (p = 0.599). Wrestling was the cause of 3 cases (3.4%); basketball, of 1 case (1.1%); and other sports, such as volleyball, handball, rugby and cycling, of 4 cases (4.7%). Among the causes not related to sports, there were 11 cases (9.3% of the total): 7 (5.9%) due to falls, and 4 (3.4%) due to traffic accidents (►Table 2).
| Non-sport-related trauma | With injury- n (%) | No injury- n (%) | p-value |
|---|---|---|---|
| Fall | 7 (5.9%) | 64 (54.2%) | 0.939 |
| Traffic accident | 4 (3.4%) | 43 (36.5%) | |
| Total (100%) | 11 (9.3%) | 107 (90.7%) | |
| Sport-related trauma | With injury- n (%) | No injury- n (%) | p-value |
| Soccer | 68 (9.6%) | 548 (77.6%) | 0.599 |
| Wrestling | 3 (0.4%) | 25 (3.5%) | |
| Basketball | 1 (0.1%) | 14 (2.0%) | |
| Other | 4 (0.7%) | 43 (6.1%) | |
| Total (100%) | 76 (10.8%) | 630 (89.2%) |
The annual incidence rate is illustrated in ►Table 3, and shows that, apart from 2018 (5.2%), there was a progressive increase in the incidence of ramp injuries, ranging from 4.0% in 2014 to 20.6% in 2019.
| Year | Total exposed (n) | Ramp lesion (n) | Incidence (%) | 95%CI | |
|---|---|---|---|---|---|
| LL | UL | ||||
| 2014 | 124 | 5 | 4.00 | 1.70 | 9.10 |
| 2015 | 89 | 4 | 4.50 | 1.80 | 11.00 |
| 2016 | 110 | 12 | 10.90 | 6.40 | 18.10 |
| 2017 | 104 | 12 | 11.50 | 6.70 | 19.10 |
| 2018 | 116 | 6 | 5.20 | 2.40 | 10.80 |
| 2019 | 281 | 48 | 20.60 | 15.10 | 21.90 |
| Total | 824 | 87 | 10.60 | 8.60 | 12.80 |
DISCUSSION
The main findings of the present study were the incidence of meniscal ramp lesions in 10.6% of the patients with ACL injuries, and the highest incidence among those with chronic ACL lesions. Other authors reported values between 9% and 24%.1,6,9,10,14-16 Bollen6 and Di Vico et al.,15 reported lower incidences, of 9.3% and 9.6% respectively. Both studies included a smaller sample, respectively of 183 and 115 patients. Liu et al.,10 with a sample of 868 patients, observed an incidence of 16.6%, which is closer to that found in the present study. The studies that found the highest incidences were those by Seil et al.14 and by Sonnery-Cottet et al.,1 both with 24% of cases of ACL injury, and analyzing 224 and 3,214 patients respectively. This great variation in the results found in the literature may be the result of certain factors, such as the experience and ability of the surgeons to diagnose the lesion during the arthroscopic procedure, and the number of patients included in the sample. It was evident in the present study that there was an important annual increase in the incidence of ramp injuries, from 4% to 20.6%. This is attributed to the fact that the more familiar and experienced the surgeon is in investigating and repairing this injury, the greater the number of diagnoses.17
The follow-up of patients submitted to ACLR, with the medial meniscus initially considered healthy, showed that some patients still degrade the medial meniscus, although the knee seems clinically stable.18 This demonstrates that part of the lesions are underdiagnosed.
Regarding risk factors, it is known that the time between injury and ACLR is associated with an increasing incidence of medial meniscus lesions.1,19,20 Church and Keating21 found an increase in the number of all types of meniscal lesions after twelve months, recommending early ACLR to avoid these lesions. Liu et al.10 showed that, within 24 months between the ACL injury and surgery, there was an increase in the incidence of ramp injuries. In the present study, we identified that, of the cases in which this time was shorter than 3 months, 32.2% had meniscal ramp lesion, while 49.1% had no signs of injury. In chronic cases, with a time longer than 3 months, there was a proportional increase in cases with ramp injury (67.8%) compared to cases in which the meniscus was intact (50.9%) (p = 0.008).
Regarding the review cases, the literature22-24 shows that knees submitted to ACL review have more intra-articular lesions than knees submitted to primary reconstruction. Wright et al.25 showed that up to 90% of the ACL revision cases presented a meniscal or condral lesion, while 57% had both lesions at the time of surgery. Like Sonnery-Cottet et al.,1 we chose to include in the study patients submitted to ACL review, seeking to evaluate whether this could also be considered a risk factor. Interestingly, the data found in the present study did not show a higher incidence when it comes specifically to meniscal ramp lesions in review cases (p = 0.562).
Despite the incidence of 10.6% of ACL reconstruction surgeries, the annual incidence in the period studied ranged from 4.0% in 2014 to 20.6% in 2019. This escalation in the number of cases draws attention, and may demonstrate a significant learning curve in the diagnosis and treatment of these lesions. Therefore, we recommend the establishment of routine systematic inspections of the posteromedial compartment of the knee in ACL reconstructions, especially in chronic cases.
The present study has some limitations. During the first years, some cases may have been underdiagnosed, due to the learning curve, presenting an incidence slightly below the real one. Moreover, although both surgeons had great experience in ACLRs, they were not necessarily at the same point of the learning curve for the diagnosis and repair of meniscal ramp lesions during the period studied. This may have influenced the final result and the annual incidence. Another possible bias is the fact that both surgeons are right-handed, which may justify the greater number (statistically significant) of right laterality, perhaps because it was easier from a technical point of view, or because of the preference of the surgeons in the first cases. The present study also has strengths, such as the significant sample (824 patients) compared to the samples of other similar epidemiological studies in the literature. The fact that the study involved more than one service strengthens the article, which analyzes the epidemiology of these lesions under the same arthroscopic exploration protocol, however, in different regions of the Brazilian territory. In any case, further epidemiological studies should be conducted in different centers and regions of Brazil. With a more information and data from different knee surgeons, there will be a better understanding of the risk factors and the incidence of meniscal ramp injuries among the Brazilian population.
CONCLUSION
The incidence of meniscal ramp lesions was of 10.6% in ACLRs, being more frequent in chronic lesions. The annual incidence in the period studied ranged from 4.0% in 2014 to 20.6% in 2019.
