ABSTRACT:
OBJECTIVE To assess the role of facet tropism (FT) in intervertebral disc prolapse.
METHODS A total 98 patients with lower back pain were included in the study. Magnetic resonance
imaging scans were performed and analyzed. The angles of the right and left facets
were measured on the axial section. Patients without disc prolapse at the L3-L4, L4-L5
and L5-S1 levels act as controls for those with disc prolapse at the same levels.
A statistical analysis was also performed.
RESULTS The incidence of FT at the L3-L4 level was of 85.2% in patients with disc herniation
(n= 27), and of 56.3% in the control group, which was statistically significant (p= 0.008). Similarly, at the L4-L5 level, incidence of FT among cases and controls
was of 71.4% (n= 35) and 52.4% respectively (p= 0.066). At the L5-S1 the incidence was of 66% and 51% among cases and controls respectively
(p= 0.13).
CONCLUSION We found a positive association between FT and disc herniation at the L3-L4 level,
but no association at the L4-L5 and L5-S1 levels.
Keywords: degeneração do disco intervertebral; vértebras lombares; espondilolistese; ressonância magnética.
RESUMO:
OBJETIVO Avaliar o papel do tropismo facetário (TF) no prolapso discal intervertebral.
MÉTODOS Um total de 98 pacientes com dor lombar foram incluídos no estudo. Exames de ressonância
magnética foram realizados e analisados, e os ângulos das facetas direita e esquerda
foram medidos na seção axial. Os pacientes sem prolapso discal nos níveis L3-L4, L4-L5
e L5-S1 atuam como controles para aqueles com prolapso nos mesmos níveis. Fez-se também
uma análise estatística.
RESULTADOS A incidência de TF no nível L3-L4 foi de 85,2% em pacientes com hérnia discal (n= 27), e de 56,3% no grupo controle, o que foi estatisticamente significativo (p= 0,008). Da mesma forma, a incidência de TF no nível L4-L5 entre casos e controles
foi de 71,4% (n= 35) e 52,4%, respectivamente (p= 0,066). No nível L5-S1, a incidência foi de 66% e 51% nos caso e nos controles,
respectivamente (p= 0,13).
CONCLUSÃO Encontramos associação positiva entre TF e hérnia de disco no nível L3-L4, mas nenhuma
associação nos níveis L4-L5 e L5-S1.
Palavras-chave: intervertebral disc degeneration; lumbar vertebrae; spondylolisthesis; magnetic resonance.
FIGURES
| Citation: Yadav S, Arya R, Dakshinamoorthy R, Jha AA, Jain S, Kumar I. Facet Tropism/Inclination and Its Association with Intervertebral Disc Herniation in the Lumbar Spine – A Radiological Evaluation* . 57(06):941. doi:10.1055/s-0042-1742338 |
| Financial Support There authors declare they have received no financial support from public, commercial, or non-profit sources. |
|
Conflict of Interests: The authors have no conflict of interests to declare. |
|
*Study developed at the Department of Orthopedics, Institute of Medical Sciences, Banaras Hindu University, India. |
| Received: July 31 2021; Accepted: October 14 2021 |
INTRODUCTION
Facet joints connect adjacent vertebrae, and they are synovial joints that help in flexion, extension, and rotation of the spine. For each disc space, there are two facet joints and a disc, which together form a tripod that creates a motion segment. The facet joints bear ∼ 33% of the dynamic compressive load and 35% of the static load.1 2 Facet tropism (FT) is defined as an asymmetry in the angles of the facet joints of left and right sides,3 4 and it has been proposed that FT is an important cause of lumbar degenerative disc pathologies and spondylolisthesis.5 6 When symptomatic, such condition often requires surgical intervention. In 1927, Putti7 proposed the significance of asymmetrical zygapophyseal joints in the pathogenesis of low back pain. Asymmetry in facet orientation was determined to be a normal feature in thoracic vertebrae, but not in lumbar vertebrae. It has been proposed that, in the lumbar segment, this may be due to a pathological condition.
There is conflicting evidence regarding the association between tropism and prolapsed disc. It has long been thought that disc degeneration in the spine can change the kinematics and load distribution, resulting in secondary structural and morphological effects on the facet joints and their orientation. Contrary to that view, asymmetry in the facet joints increases the motion at a particular segment and reduces tolerance to anterior shearing forces.8 9 This can exacerbate the degeneration process in both the disc and facet joints, resulting in prolapsed intervertebral disc.4 Van Schaik et al.10 showed a significant relationship between lower back pain and intervertebral disc prolapse at the L4-L5 level. Farhan and Sullivan11 first suggested the correlation between FT and the development of lumbar disc prolapse. However, the role of FT in the pathogenesis of disc prolapse is still unclear. In the present study, we aim to analyze the correlation between tropism in the facet joints and degenerative disc prolapse, as well as the association between the severity of FT and disc prolapse. Identifying the role of facet inclination in intervertebral disc prolapse can enhance our understanding of the pathophysiology of the facet joints and improve the treatment and management of disc prolapse.
METHODS
The present is a cross-sectional study. The magnetic resonance imaging (MRI) scans of consecutive patients with back pain for more than 3 months with or without radiculopathy and aged between 19 and 64 years were analyzed over a period of 12 months. A total of 98 cases were studied, and cases with previous lumbar spine surgery, spinal deformity, or old trauma were excluded from the study.
Appropriate clearances were obtained from institutional ethics committee (IEC no. 2020/EC/2102). The study design was retrospective evaluation of MRI scans and case details available to us.
Facet tropism evaluation: The facet angles were evaluated using MRI scans of the spine. All MRIs were performed using the SIGNA 1.5T MRI scanner (GE Healthcare, Chicago, IL, US). The thickness of the image slice thickness was of at least 3 mm. T2-weighted axial film at the L3-L4, L4-L5 and L5-S1 levels with reference lines (facet line and a line along the posterior border of the vertebral body) drawn on it was selected to measure the right and left angles of the facet joints in relation to the coronal plane, which closely bisects the facet joints at each segmental level. The facet angle was calculated by intersecting the line drawn and the facet line (the line connecting the anteromedial and posterolateral tips of the superior articular facets; ►Fig. 1). The angles were measured manually using a goniometer. Facet tropism was calculated by subtracting the left and right facet angles, and FT was defined as an angulation difference ≥ 7° in the coronal orientation of the left and right facet angles. We used the FT/facet inclination (FI) grading method developed by Ko et al.12 as follows: grade 0 if FI ≤ 6°; grade 1 if the FI ranges from 7° to 15°; and grade 2 if FI ≥ 16° (►Table 1). Patients with grades 1 and 2 FI are considered to have FT, and grade 2 is considered severe.
| Explanation | Grade | Angle of the facet tropism |
|---|---|---|
| No facet tropism (no asymmetry) | Grade 0 | ≤ 6° |
| Moderate facet tropism (moderate asymmetry) | Grade 1 | 7°–15° |
| Severe facet tropism (severe asymmetry) | Grade 2 | ≥ 16° |
Disc herniation was also evaluated at the levels from L3 to S1. Patients without disc prolapse between levels L3 and S1 acted as controls for those having disc prolapse at the same levels. Data was recorded on a Microsoft Excel (Microsoft Corp., Redmond, WA, US) spreadsheet. The statistical analysis was performed using the Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY, US) software, version 22.0. Data was reported as means and standard deviations. The relationship between disc herniation and FI was evaluated using the Chi-squared test. Statistical significance was set as p-values ≤ 0.05.
RESULTS
Magnetic resonance imaging (MRI) scans of 98 patients (54 male and 44 female patients) were evaluated. The average age of the sample was 42.1 years; that of the male patients was 42.3 years, and that of the female patients was 41.9 years. No significant gender difference was found regarding FT. A total of 294 lumbar levels (588 facet angles) were studied, including the levels from L3 to S1.
Overall facet joint angulation: The mean right and left FIs and cases with variable FI at the levels between L3 and S1 are detailed in ►Table 2. The prevalence of FI variability according to the tropism grading is shown in ►Table 3, which also shows the incidence rate of the total of cases of FT versus the severe cases. At the L3-L4 level, the rate of severe FT was of 8.2%; at the L4-L5 level, 6.1%; and, at the L5-S1 level, 3.1%.
| Segment level | Facet angle (minimum; in degrees) | Facet angle (maximum; in degrees) | Mean facet angle (in degrees) | Presence of tropism (n) | Absence of tropism (n) |
|---|---|---|---|---|---|
| L3-L4 (right) | 23 | 70 | 43.2 ± 9.01 | 36 | 62 |
| L3-L4 (left) | 19 | 69 | 46.4 ± 9.23 | ||
| L4-L5 (right) | 15 | 68 | 42.7 ± 9.53 | 31 | 67 |
| L4-L5 (left) | 19 | 74 | 44 ± 10.01 | ||
| L5-S1 (right) | 17 | 56 | 39.02 ± 8.06 | 31 | 67 |
| L5-S1 (left) | 16 | 65 | 41.9 ± 9.31 |
| Segment level | Facet tropism grade* | Number of patients | Incidence rate (total of cases/severe cases**; %) |
|---|---|---|---|
| L3-L4 | 0 | 62 | 36.7/8.2 |
| 1 | 28 | ||
| 2 | 8 | ||
| L4-L5 | 0 | 66 | 32.6/6.1 |
| 1 | 26 | ||
| 2 | 6 | ||
| L5-S1 | 0 | 67 | 31.6/3.1 |
| 1 | 28 | ||
| 2 | 3 |
**Severe tropism defined as grade 2 (according to the method of Ko et al.12).
Correlation between FT and disc herniation: The relationship between lumbar disc herniation and variable FI/FT is described in ►Table 4. The correlation at the L4-L5 level was the most statistically significant (p= 0.007) followed by the L3-L4 level (p= 0.03).
| Spinal level | Disc herniation –n (%) | Facet tropism –n (%) | p-value | ||
|---|---|---|---|---|---|
| Yes | No | ||||
| L3-L4 | Present | 27 (27.6) | 14 (51.8) | 13 (48.2%) | 0.038 |
| Absent | 71 (72.4) | 22 (30.9) | 49 (69.1%) | ||
| L4-L5 | Present | 35 (35.7) | 17 (48.5) | 18 (51.5%) | 0.007 |
| Absent | 63 (64.3) | 13 (23.1) | 50 (76.9%) | ||
| L5-S1 | Present | 47 (47.9) | 19 (40.4) | 28 (59.6%) | 0.073 |
| Absent | 51 (52) | 12 (23.5) | 39 (76.5%) | ||
DISCUSSION
The orientation of the facet joints bears a considerable role in understanding the biomechanics of the lumbar spine. For their coordinated movements, a symmetrical alignment of both sides of the facet joint is necessary. Asymmetrical facet joints result in abnormal loading of the spinal motion segments. There are few studies which report the association between FI variability and lumbar disc herniation, and their results are not consistent. Facet joint orientation and bilateral variability can be assessed using MRI without exposure to harmful radiation.3 The usual course of facet joint pathologies is not very clear, and a few studies4 13 14 15 suggest that FT may be due to a biological remodeling process secondary to disc changes and instability of the spine in the rotational axis. A few studies16 17 18 also suggest a developmental origin.
The current study establishes that tropism/bilateral variability exists in lumbar levels irrespective of the degenerative changes. This challenges the notion that facet orientation is related to remodeling changes caused by spine degeneration. The L3-L4 joint is more rounded and resists both anterior and lateral translations, whereas the L5-S1 joint is flat and oriented more in the coronal plane. This provides higher resistance to anterior shear stresses. Facet joint orientation in the axial plane in patients with spondylolisthesis in this region presented a variation up to 15° in one study.19
Kalichman et al.17 18 and Farfan and Sullivan11 reported that the angle of the lumbar facet joint and lumbar disc herniation were significantly linked to the asymmetry of the lumbar facet joint and its severity. Similar results were found in the present study.
In another study, Noren et al.20 found that FT is a risk factor in the development of disc disease. Asymmetrical and sagittally-inclined facet joints were present in patients with lumbar disc prolapse, especially taller subjects, in the study by Karacan et al.4 Cyron and Hutton14 hypothesized that variable facet orientation can lead to segmental instability. This can increase the rotational strain on the annulus fibrosus and lead to disc prolapse. In another study, Chadha et al.21 reported a considerable association between FT and disc prolapse at the L5-S1 level, but no association at the L4-L5 level.
On the other hand, some researchers10 20 22 23 have suggested that FT has no clinical significance. They consider it to be a congenital structural problem rather than one due to age or degeneration, and propose that there is no association between the facet angle and disc herniation.
Various other works24 25 have also demonstrated that the axial torque-rotation response in the lumbar spine is unaffected by the orientation of a facet joint with a similar degree of asymmetry at all levels. Lee et al.26 found no significant difference in FT between herniated and normal discs in both adolescent and adult groups, except at the L4-L5 level in adults.
On flexion-extension, the more coronally-oriented facet joint restricts movement in the sagittal plane, causing involuntary rotation along the more sagittally-oriented facet joint. Masharawi et al.8 have explained how FT may convert movements in one plane into a complex multiplanar movement. The nucleus shifts posterolaterally in an unbalanced manner when flexion and torsion are coupled. The combination of flexion and torsion has been shown in many biomechanical studies27 28 to cause injury to the posterolateral annulus.
In the present study, intervertebral disc prolapse was especially associated with FT at L3-L4 and L4-L5 levels, with a statistically insignificant association at the L5-S1 level. This can be explained by different loading patterns at different levels. The biomechanics at L4-L5 level and those above it is different from that of the L5-S1 level, as the L4-L5 level lies between 2 mobile segments, and the L5-S1 level lies between mobile and fixed segments. Further, the L5-S1 disc is subjected to higher anteroposterior shear forces because of the increased inclination at S1 and the absence of a protective role of the extensor muscles.21 29 The high correlation between FT and disc prolapse reported at L4-L5 but not at L5-S1 might thus be explained by a variation in loading pattern.
There present study has several limitations. First, it is a single-center study with a small sample size. Second, errors may have been made in locating the margins and reference plane of the facet joint. Osteophytes in the facet joint can lead to errors in the measurement of the facet angle. Third, it is not feasible to analyze FT as an isolated factor; other degenerative changes such as asymmetric disc degeneration may also affect FT; hence, further studies on the pathological mechanisms of FT are needed. One of the strengths of the study is the inclusion of patients without disc prolapse at the same level as controls for comparison, instead of considering the adjacent segment, as in many previous studies. Nevertheless it would have been better had the controls been obtained by performing MRI scans in asymptomatic subjects.
CONCLUSION
Clinical significance: The present study showed a positive association between facet inclination variability and disc herniation at the L4-L5 level, followed by the L3-L4 level. Facet orientation may guide which side to approach for surgical decompression when needed. Long-term follow up may help in deducing the natural history of facet orientation variability.
