ABSTRACT:
OBJECTIVE Hip osteoarthritis (HO) causes pain and deranges functioning. Surgical
treatment is the preferred approach in severe cases, but clinical
comorbidities, age and the long waiting list may compromise quality of life.
This study aimed to describe the results of acupuncture for the control pain
and improvement of functioning in subjects with HO.
METHOD Twelve severe HO patients were treated with ten weekly sessions of a
standardized acupuncture point protocol. Pain intensity was assessed with
the Visual Analog Pain Scale (VAS) and quality of life with WOMAC Index.
RESULTS Pain intensity (VAS) reduced from 75.8 ± 18.8 mm to 20.0 ± 22.6 mm after 10
acupuncture sessions and 48.3 ± 26.6mm in the follow-up (ANOVA F = 7.99; p
< 0.001). WOMAC Index values reduced from 74.7 ± 12.7 to 45.7 ± 22.1 and
54.6 ± 22.9 at the same timepoints.
CONCLUSION Acupuncture is an effective conservative rehabilitation strategy to reduce
pain and improve quality of life in subjects with severe HO.
Keywords: osteoarthritis; hip; acupuncture; pain; quality of life.
RESUMO:
OBJETIVO A osteoartrite (OA) de quadril causa dor e perda da funcionalidade. O
tratamento cirúrgico é a procedimento de escolha nos casos graves, mas as
comorbidades clínicas, a idade e a longa lista de espera podem comprometer a
qualidade de vida. Este estudo teve como objetivo descrever os resultados da
acupuntura no controle da dor e melhora da funcionalidade em indivíduos com
OA de quadril.
MÉTODO Doze pacientes com OA de quadril grave foram tratados com dez sessões
semanais de um protocolo padronizado de pontos de acupuntura. A intensidade
da dor foi avaliada pela Escala Visual Analógica de Dor (EVA) e a qualidade
de vida pelo Índice WOMAC.
RESULTADOS A intensidade da dor (EVA) reduziu de 75,8 ± 18,8mm para 20,0 ± 22,6mm após
10 sessões de acupuntura e 48,3 ± 26,6mm no período de seguimento (ANOVA F =
7,99; p < 0,001). Os valores do Índice WOMAC reduziram de 74,7 ± 12,7
para 45,7 ± 22,1 e 54,6 ± 22,9 nos mesmos momentos.
CONCLUSÃO A acupuntura é uma estratégia de reabilitação conservadora eficaz para
reduzir a dor e melhorar a qualidade de vida em indivíduos com OA de quadril
grave.
Palavras-chave: acupuntura; dor; qualidade de vida; osteoartrite; quadril.
FIGURES
| Citation: Astini R, Riberto M. Acupuncture in the Treatment of a Series of Patients with Chronic Pain Associated with Hip Osteoarthritis. 58(5):e750. doi:10.1055/s-0043-1776134 |
| Financial Support: This study was suported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. |
|
Conflict of Interests: Dr. Rafael Astini and Dr. Marcelo Riberto reported that This study was
suported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior –
Brasil (CAPES), and research incentive grants, paid to the authors. |
|
Work developed in the Hospital das Clínicas da Faculdade de Medicine of Ribeirão Preto da Universidade de São Paulo, RibeirãoPreto, SP, Brazil. |
| Received: February 03 2023; Accepted: June 26 2023 |
INTRODUCTION
Hip osteoarthritis (HO) is a prevalent joint disease which is characterized by pain both during rest or, most commonly, while standing, walking, and moving around. The treatment of HO aims to relieve pain and restore functioning and quality of life. Severe anatomic impairment of the joint is satisfactorily treated with hip replacement, but old age, comorbidities 1 and the long waiting lists for this procedure in the Brazilian public health system 2 demand conservative analgesic and rehabilitative interventions for these patients.
Acupuncture, used in China and other Asian countries over the last 3,000 years, represents a valuable complementary therapy for pain control, 3 in addition to representing lower health costs by reducing the number of prescription drugs and hospitalizations. 4
A recent systematic review on the effects of acupuncture on HO concluded, however, that acupuncture has little or no effect in reducing pain or improving function relative to sham acupuncture. 5 However, many studies included in this review have methodologic limitation and comprise control groups with a weak acupuncture effect. Given this scenario, acupuncture should be tested as a conservative treatment to total hip replacement (THR).
This study aimed to describe the results of acupuncture treatment for analgesia and improved quality of life in a series of patients with severe HO in a waiting list for THR.
METHODS
This study was approved by the Internal Review Board at the Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (HCRP) (Protocol 4,105,165 and CAAE 32396920.9.0000.5440) and the subjects signed an informed consent form.
Five women and seven men with severe HO (mean age: 57.9 ± 10.6 years) were prospectively recruited of rehabilitation outpatient clinic from June 2020 to January 2021. The sample size was calculated using the Sample Size Calculation tool from the MGH Biostatistic Center. Eleven participants were required for 80% power to detect difference of 25% in the pain VAS, assuming SD= 25mm and significance level of 0.05. We started the study with fifteen participants to prevent dropout losses and ended the study with a total of twelve individuals. The COVID19 pandemic restricted sample size because of the health care interruption. Quantitative variables were summarized by measures of central tendency and dispersion, while categorical variables were classified and summarized by percentages of categories. After verifying the normality of the distribution of variables, the ANOVA test for repeated measures was used to test the hypothesis that pain intensity and functioning would improve with treatment. The significance level was 0.05.
Subjects should be adults diagnosed with unilateral HO according to clinical criteria, 6 be classified as grade three or four in the Kellgren-Lawrence radiological classification, 7 present with pain intensity greater than four assessed by the Visual Analog Scale (VAS), failure in conservative treatment consisting of: exercises, pharmacological therapies such as analgesics or anti-inflammatory drugs, use of walking aids, or no improvement when performing trigger point blocks 8 ; and not being previously treated with acupunture were also required. Exclusion criteria included any limitation to understand the assessment or treatment, difficulty in clinical follow-up and attendance at reassessments for any reason, other diagnoses of hip or other lower limb painful condition.
The first assessment was performed immediately after recruitment and subjects pain intensity was assessed with VAS, 9 The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) considers three dimensions of functioning of HO: pain (range 0-20 points), stiffness (range 0-8 points) and physical function (range 0-68 points), 10 and the ten-meter walk test (performed on a flat, 14-meter straight surface for the highest possible walking speed). 11 The Medication Consumption Diary quantified the use of analgesics and anti-inflammatories to relieve pain. 12 Two other evaluations were performed immediately after treatment and five weeks after the end of treatment.
For ten acupuncture sessions, subjects were laterally positioned over the unaffected side. The treatment was performed by the same physician (RA - five years of acupuncture practice, board certified) with deep insertion of sterile acupuncture needles (0.30mm diameter, 70mm length) until the “de Qi” sensation for 20 minutes. Six points were used: GB29, GB30, GB34, GB36, BL62, SJ5 13 , 14 based on Traditional Chinese Medicine (TCM) techniques. 15
All participants also received the standard treatment at the HCRP Rehabilitation Center, which includes physiotherapy at the institution and behavioral and exercise guidance at home, as well as the use of optimized medications.
RESULTS
All twelve patients remained until the end of the study. The biodemographic and baseline clinical data of HO subjects is illustrated in ► Table 1 .
| Baseline biodemographic and clinical data of HO subjects | |
|---|---|
| Variable | n (%) |
| Gender | Subjects |
| Male | 7 (58.4%) |
| Female | 5 (41.6%) |
| Affected Side | |
| Right | 2 (16.7%) |
| Left | 10 (83.3%) |
| Variable | Mean (SD) |
| Age (years) | 57.9 (10.6) |
| Diagnosis Time (years) | 19.5 (14.0) |
| VAS (mm) | 75.8 (18.8) |
| WOMAC (points) | 74.7 (12.7) |
| Ten-meter walk test (seconds) | 17.4 (14.9) |
Pain intensity (VAS) reduced from 75.8 ± 18.8mm to 20.0 ± 22.6mm after 10 acupuncture sessions and 48.3 ± 26.6 mm in the follow-up (► Fig. 1 -ANOVA F = 7.99; p < 0.001). After treatment, there was a significant decrease in mean pain of 55.8 ± 28.4mm on the 100 mm VAS (p < 0.001), which corresponded to a reduction of 73.6%. At the follow-up assessment, the VAS increased, but did not return to baseline levels.
Mean WOMAC scores decreased significantly from 74.7 ± 12.7 (pre-treatment) to 45.7 ± 22.1 (post-treatment; p = 0.003) and 54.6 ± 22.9 (five-weeks follow-up; p = 0.02) (► Fig. 2), demonstrating a lasting effect for more than five weeks.
Significant changes were not observed in mean ten-meter walk tests scores. Subjectively, all patients reported improvement in pain, and quality of life, and reduced pain killing drugs consumption. Eight participants did not use medication in the last week of treatment; and the four participant who needed daily medication reduced its consumption by 70%. No serious adverse effects of acupuncture treatment were observed; some patients felt pain or slight bleeding at the needle insertion sites, with spontaneous resolution within a few seconds.
DISCUSSION
This case series confirmed our initial hypothesis of the potential therapeutic use of acupuncture in subjects with a severe HO indicated for THR, because of substantial improvement pain, functioning, and quality of life summed to reduction in analgesics and anti-inflammatory drugs consumption, but not in terms of walking speed.
Two randomized clinical trials compared real acupuncture with a control group. Fink et al. 13 and White et al. 16 demonstrated a reduction in mean EVA of 18 mm and 17 mm, respectively, after treatment with acupuncture, which was much less than 55.8 mm as we observed. Wider improvement in pain control is explained by the selection subjects with more intense pain (VAS = 75.8 ± 18.8 mm; while Fink had mean baseline of 54.6 ± 18.9 mm and White, 60.5 ± 14.2 mm), although total number and duration of sessions was similar.
Also, the choice of more effective acupuncture points may explain the more intense results. While Fink used a protocol of local and distant points for all patients (Ashi points on the hip, GB30, GB31, GB34, E40, B37, and B54), White let the therapist free to choose acupuncture points of his preference. Out of the TCM theories of energy harmonization, the cumulative and lasting effect of acupuncture can be explained by the reduction of nociceptive input, which may lead to improved mobilization of joints and lower limbs, which result in less limitation and progressive pain control. Additional acupuncture sessions may strengthen the initial analgesic effect and enhance a virtuous therapeutic cycle.
Functioning improvement assessed by WOMAC was documented in studies with anti-inflammatory 17 or analgesic drugs or pain controlling procedures like obturator nerve block, 18 which are therapeutic interventions in which the anatomic deformities of HO are not modified. For patients undergoing THR, mean WOMAC reduction ranges from 50 to 70 points after surgery. 19 This study demonstrated that acupuncture decreased WOMAC scores by 29 points.
Insertion of the acupuncture needle stimulates a wide peripheral neural network and reaches the central nervous system, promoting a phenomenon of neuromodulation at three levels - local, spinal, and supraspinal - resulting in the release of various substances, mainly neurotransmitters such as opioid peptides (enkephalin, dynorphin, and beta endorphin) and monoamines (serotonin, norepinephrine, histamine, dopamine), modulating motor, sensory, autonomic, neuroendocrine, and emotional functions. 20 For this, we use local hip points and distant points that act indirectly on the hip region or musculoskeletal structures. Points GB29 and GB30, are closely related to local neuromuscular structures: GB29 is superficially related to the tensor fasciae latae muscle, the lateral cutaneous nerve of the thigh; and deeply related to the muscular branches of the femoral nerve. 15 GB30 is superficially related to the gluteus maximus muscle and the inferior margin of the piriformis muscle, as well as with the middle cluneal nerves; and deeply related to the inferior gluteal and sciatic nerves. 15 Riberto et al. 21 described the presence of trigger points associated with myofascial pain syndrome and the symptom of persistent pain and disability in patients with HO, and later described the result of treating this syndrome with 1% lidocaine blockade for reduced pain and increased pressure pain measurement. 22 The muscles in which trigger points were most frequently identified in these studies were: piriformis (20%), iliopsoas (18%), long adductor (18%), gluteus medius (12%), gluteus minimus (12%), which are penetrated while needling of points GB29 and GB30.
The benefits demonstrated in this article are the result of ten acupuncture sessions, performed during five weeks, however, acupuncture can be maintained indefinitely, further prolonging its effect. Furthermore, this therapeutic modality has no absolute contraindications 23 and reports of serious adverse effects are rare. 24
Given that this is a pilot project, this series of cases has limitations regarding its sample size and lack of comparison with control groups. The clinical follow-up period of patients was relatively short: only ten weeks; but for patients with such intense and prolonged complaints, the intensity and duration of the results were clinically significant. We suggest a randomized controlled trial to confirm the therapeutic superiority of real acupuncture over sham acupuncture or conventional treatment.
CONCLUSION
Acupuncture is an effective conservative rehabilitation strategy to reduce pain and improve quality of life in subjects with severe HO, and these benefits can lasts for at least five weeks post-treatment.
